Unlike Bone, Cartilage Regeneration Remains Elusive

Unlike bone, cartilage regeneration remains elusive.

Articular cartilage was predicted to be one of the first tissues to successfully be regenerated, but this proved incorrect. In contrast, bone (but also vasculature and cardiac tissues) has seen numerous successful reparative approaches, despite consisting of multiple cell and tissue types and, thus, possessing more complex design requirements. Here, we use bone-regeneration successes to highlig...

Bone & Cartilage Regeneration News 01/2009

BMPs and Wnts in Bone and Cartilage Regeneration

© Springer International Publishing Switzerland 2015 H. Zreiqat et al. (eds.), A Tissue Regeneration Approach to Bone and Cartilage Repair, Mechanical Engineering Series, DOI 10.1007/978-3-319-13266-2_2 Abstract Bone morphogenetic proteins (BMPs) play an important role in osteoblast and chondrocyte differentiation and canonical Wnt signaling regulates bone mass. BMP-2 is approved for use in spi...

Cartilage and Bone Regeneration – How close are we to bedside?

The treatment/regeneration of bone and cartilage diseases or defects, whether induced by rheumatism, joint dysplasia, trauma, or surgery presents great challenges that have not been fully solved by the current therapies. In the last few years, tissue engineering and regenerative medicine have been proposing advanced tools and technologies for bone and cartilage tissue regeneration, and some of ...

Joints: Regeneration of Bone, Cartilage, Meniscus, Ligament, and Tendon